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BiologyBiologyHigh school

Genetics

Mendelian inheritance and Punnett squares.

Genetics explains how traits pass from parents to offspring. Genes are stretches of DNA, and each gene can come in different versions called alleles. You inherit one allele of each gene from each parent, and the combination, your genotype, determines the trait you show, your phenotype.

A dominant allele masks a recessive one, so a person with genotype AaAa looks the same as AAAA. Punnett squares predict the probabilities of offspring genotypes. Crossing two heterozygous parents (Aa×AaAa \times Aa) gives the classic 1:2:11:2:1 genotype ratio and 3:13:1 phenotype ratio.

Key terms

Monohybrid cross
A cross of two heterozygotes gives a 3:1 phenotype ratio for a dominant trait.

Key ideas

  • Homozygous: two identical alleles (AAAA or aaaa); heterozygous: two different (AaAa).
  • Each parent passes on one allele at random, which is why outcomes are probabilities.
  • A test cross with aaaa reveals whether a dominant-looking individual is AAAA or AaAa.
  • Independent genes multiply: a dihybrid cross gives 9:3:3:19:3:3:1.

Worked example

Two heterozygous pea plants (TtTt, tall dominant) are crossed. What fraction of offspring are short?

  1. Each parent gives TT or tt with probability 12\frac{1}{2}.
  2. Punnett square outcomes: TTTT, TtTt, tTtT, tttt.
  3. Only tttt is short: 14\frac{1}{4}.
  4. Phenotype ratio: 3 tall : 1 short.

Answer: 14\frac{1}{4}

Common mistakes

  • Expecting exact ratios in small families rather than probabilities.
  • Confusing genotype with phenotype.
  • Thinking dominant alleles are more common in the population.

Practice questions

Try each one, then open the answer. Numerical answers on this page are verified by an automated calculation check.

  1. 1.In Aa×aaAa \times aa, what fraction of offspring show the recessive trait?

    Show answer

    12\frac{1}{2}

  2. 2.In Aa×AaAa \times Aa, what fraction are heterozygous?

    Show answer

    12\frac{1}{2}

  3. 3.In AaBb×AaBbAaBb \times AaBb with independent genes, what fraction show both recessive traits?

    Show answer

    116\frac{1}{16}

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